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KMID : 0357119920140010107
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Korean Journal of Immunology
1992 Volume.14 No. 1 p.107 ~ p.116
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In Vivo Effect of Morphine, Meperidine and Naloxone on Immune Response in Mice
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Abstract
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Recently it is generally accepted that exogenous and endogenous opioid peptides play a crucial role in the regulation of the immune function. However, there little information regarding the effect of morphine, meperiding and/or naloxone on in
vivo
cellular and humoral immune response. Thus, the present sftudy was undertaken in an effort to investigate the in vivo effect of morphine, meperidine and/or naloxone on cellular and humoral immune responses in mice. The immune responses
investigated
were
delayed-type hypersensitivity (DTH0 reactions to sheep red blood cells(SRBC0, contact hypersensitivity to dinitroflluorobenzene(DNFB0, and antibody responses to polyvinylpyrrolidone(PVP), a thymus-independent antigen, and SRBC, a thymus-dependent
antigen. Naloxon(15μg) given daily once or twice a day for 5 days resulted in enhancement of DTH to SRBC and contact hypersensitivity to DNFB, but did not affect significantly antibody response to SRBC and PVP. Meperidine (340μg), given daily
or
twice
a day for 5 days significanlty inhibited the DTH and contact hypersensitivity reactions, and meperidine given twice a day for 6 days also profoundly suppressed antibody responses to SRBC and PVP, but meperidine given once a day did not influence
the
antibody response. Morphine (50μg), given daily once or twice a day for 5 days, significantly inhibited the DTH and contact hypersensitivity reactions, an morphine given tswice a day for 6 days did not affect the antibody response. The
suppression
of
cellular and hymoral immune responses caused by meperidine or morphine administration into mice was reversed by concomittant injetion of naloxone. Taken togother, enhancement of DTH reaction to SRBC and of contact hypersensitivity to DNFB by
naloxone
itself and reversibility of opiates' immunosuppresive activity by naloxone strongly suggest that exogenous opioid system in mice may play a very important role in induction and expredssion of immune response, and these data also provide eviedence
that
exogenouse meperidine and morphine profoundly inhibit the in vivo cellular and humoral immune resonses.
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KEYWORD
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